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MKK4 Antibody [MEK4]

CAT: 0800-R31399Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31399Size:100 µg
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Description
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4), also called MEK4, SEK1, JNKK1 and MKK4, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P45985
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human MKK4/MEK4 (ELLKHPFILMYEERAVEVA) was used as the immunogen for this MKK4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the MKK4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MKK4 antibody is available for research use only.
Storage Conditions
After reconstitution, the MKK4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MKK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of MKK4 antibody and Lane 1: rat skeletal muscle; 2: HeLa; 3: A549; 4: MM231; 5: CEM lysate. Predicted molecular weight ~44 kDa.

UniProtKB · P45985

Dual specificity mitogen-activated protein kinase kinase 4

MP2K4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P45985
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2K4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase kinase 4, MAPKK 4
EC number
2.7.12.2
Processing
—
Secondary accessions
B2R7N7, B3KYB2, D3DTS5, Q5U0B8, Q6FHX4, Q6P9H2, Q6PIE6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationMethylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisStress response

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

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Alternative Products

CatalogName
AF6322-01MEK4/MKK4 Antibody
AF3322-01Phospho-MEK4/MKK4 (Thr261) Antibody
NBP3-03652-100ulRabbit Polyclonal MKK4/MEK4 Antibody
AF4434-01Phospho-MEK4/MKK4 (Ser257) Antibody
AF3321-01Phospho-MEK4/MKK4 (Ser80) Antibody
NBP1-47839Mouse Monoclonal MKK4/MEK4 Antibody (OTI8A8)
NBP2-99331HRabbit Polyclonal MKK4/MEK4 Antibody [HRP]
NBP2-99331BRabbit Polyclonal MKK4/MEK4 Antibody [Biotin]
NBP2-99331PCPRabbit Polyclonal MKK4/MEK4 Antibody [PerCP]
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