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MEK3 Antibody / MAP2K3 / MKK3

CAT: 0800-R30447Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30447Size:100 µg
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Description
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P46734
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human MEK3 (RNLDSRTFITIGDRNFE) was used as the immunogen for this MEK3 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MEK3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MEK3 antibody is available for research use only.
Storage Conditions
After reconstitution, the MEK3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MEK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of MEK3 antibody and Lane 1: rat skeletal muscle; 2: rat kidney; 3: rat spleen; and human samples 4: HeLa; 5: A549; 6: Jurkat; 7: CEM; Predicted size: 39KD; Observed size: 39KD

UniProtKB · P46734

Dual specificity mitogen-activated protein kinase kinase 3

MP2K3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P46734
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2K3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase kinase 3, MAPKK 3
EC number
2.7.12.2
Processing
—
Secondary accessions
B3KSK7, Q99441, Q9UE71, Q9UE72
Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Disease

Disease variant

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

Technical term

Proteomics identificationReference proteome
Product Datasheet
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