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MEK6 Antibody / MKK6 / MAP2K6

CAT: 0800-R31021Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31021Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAP2K6 (Mitogen-activated protein kinase kinase 6), also known as MAP kinase kinase 6 (MAPKK6 or MKK6) and MAPK/ERK kinase 6 (MEK6) is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17. MKK6 is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. Han et al. (1996) described experiments addressing the function of MKK6 in intracellular signaling pathways leading toward activation of p38 MAPK. Mukherjee et al. (2006) found that the Yersinia YopJ virulence factor acted as an acetyltransferase, using coenzyme A to modify critical ser and thr residues in the MKK6 activation loop, thereby blocking phosphorylation and kinase activation. They proposed that ser and/or thr acetylation by a bacterial effector may be a mechanism that occurs in other signaling pathways.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P52564
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human MKK6/MEK6 (KKRNPGLKIPKEAFEQP) was used as the immunogen for this MEK6 antibody (100% mouse homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the MEK6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MEK6 antibody is available for research use only.
Storage Conditions
After reconstitution, the MEK6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the MEK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing with Mek6 antibody and rat samples: 1. ovary; 2. spleen; 3. brain; 4. heart; 5. mouse NIH3T3; and human samples 6. HeLa; 7. Jurkat; 8. MCF-7 cell lysate. Predicted molecular weight ~37 kDa.

UniProtKB · P52564

Dual specificity mitogen-activated protein kinase kinase 6

MP2K6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P52564
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAP2K6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase kinase 6, MAPKK 6
EC number
2.7.12.2
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisStress responseTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmCytoskeletonNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

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