RIP1/RIP3/MLKL activator 1
CAT:
804-HY-144828-04
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RIP1/RIP3/MLKL activator 1
- CAS Number: 2682850-41-3
- UNSPSC Description: RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability[1].
- Target Antigen: Mixed Lineage Kinase; Necroptosis; RIP kinase
- Type: Reference compound
- Related Pathways: Apoptosis;MAPK/ERK Pathway
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/rip1-rip3-mlkl-activator-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC1=C(C(C=C2C1=CC=C3[C@]4(CC[C@]5(CC[C@@](C(NCC6=CN(N=N6)CC7=CC=C(C=C7)C(C)(C)C)=O)(CC5[C@@]4(CC[C@@]23C)C)C)C)C)=O)O
- Molecular Weight: 676.93
- References & Citations: [1]Yao Feng, et al. Synthesis and biological evaluation of celastrol derivatives as potential anti-glioma agents by activating RIP1/RIP3/MLKL pathway to induce necroptosis. Eur J Med Chem. 2022 Feb 5;229:114070.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported