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Stefin B Antibody

CAT: 0800-R31218Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31218Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cystatin B (CSTB), also called Stefin B (STFB), is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The gene is located on 21q22.3. The protein is widely distributed and is localized mostly intracellularly, but has been found extracellularly. It is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is though to be as a protector against the proteinases leaking from lysosomes. A STFB multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, STFB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of the protein is dependent on the differentiation status of the cell.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P04080
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human Stefin B (QLEEKENKKFPVFKAVSFKS) was used as the immunogen for this Stefin B antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Stefin B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Stefin B antibody is available for research use only.
Storage Conditions
After reconstitution, the Stefin B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Stefin B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Stefin B antibody; Lane 1: A549; 2: A431; 3: COLO320; 4: HeLa cell lysate. Predicted/observed molecular weight: ~11kDa.

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