LC3A/B Antibody

CAT: 0800-F54060-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
CAT#:0800-F54060-0.1MLSize:0.1 mL
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Description
LC3B is a Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9H492, Q9GZQ8
Host
Mouse
Reactivity
Human, Rat
Immunogen
A synthetic LC3B peptide was used as the immunogen for this LC3A/B antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
3E9-E5-C9
Applications
WB
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the LC3A/B antibody at -20oC.
Limitations
This LC3A/B antibody is available for research use only.
Storage Conditions
Store the LC3A/B antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the LC3A/B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) rat cerebral cortex, 2) rat brain and 3) human HeLa cell lysates using LC3A/B antibody at 1:1000. Predicted molecular weight: ~14 kDa (LC3A) and ~15 kDa (LC3B) .

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