LC3A/B Antibody

LC3A/B Antibody

• Description: LC3A:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. [UniProt]

  LC3B:Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. [UniProt]

• CAS Number: 9007-83-4
• UniProt: Q9H492, Q9GZQ8
• Host: Mouse
• Immunogen: A synthetic LC3B peptide was used as the immunogen for this LC3A/B antibody.
• Clonality: Monoclonal
• Isotype: IgG2b
• Applications: WB
• Format: Purified
• Buffer: Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
• Reconstitution: Store the LC3A/B antibody at -20oC.
• Limitations: This LC3A/B antibody is available for research use only.