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HLA-B Antibody

CAT: 0800-F40002-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40002-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin) . The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
CAS Number
9007-83-4
Specifications
Western blot: 1:100-1:250
UniProt
P03989
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 62-90 from the human protein was used as the immunogen for this HLA-B antibody.
Clonality
Monoclonal
Isotype
IgM
Clone
528CT10.4.1
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HLA-B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HLA-B antibody is available for research use only.
Storage Conditions
Aliquot the HLA-B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the HLA-B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse
Image Legend
HLA-B antibody western blot analysis in Ramos lysate. Predicted molecular weight: ~40kDa.

UniProtKB · P01889

HLA class I histocompatibility antigen, B alpha chain

HLAB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01889
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HLA-B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0A2I6Q7B5, B0V0B8, G3GN01, O02862, O02956, O02957, O02960, O19555, O19556, O19595, O19615, O19624, O19625, O19627, O19641, O19651, O19675, O19692, O19758, O19779, O19783, O46702, O62897, O62901, O62915, O62917, O62919, O77933, O77959, O78053, O78138, O78160, O78163, O78172, O78173, O78180, O78217, O95730, O98140, P01890, P03989, P10317, P10318, P10319, P10320, P18463, P18464, P18465, P19373, P30460, P30461, P30462, P30463, P30464, P30465, P30466, P30467, P30468, P30469, P30470, P30471, P30472, P30473, P30474, P30475, P30476, P30477, P30478, P30479, P30480, P30481, P30482, P30483, P30484, P30485, P30486, P30487, P30488, P30489, P30490, P30491, P30492, P30493, P30494, P30495, P30496, P30497, P30498, P30513, P30685, P79489, P79490, P79496, P79504, P79523, P79524, P79542, P79555, Q04826, Q08136, Q29633, Q29636, Q29638, Q29661, Q29665, Q29678, Q29679, Q29681, Q29693, Q29695, Q29697, Q29718, Q29742, Q29749, Q29762, Q29764, Q29829, Q29836, Q29842, Q29845, Q29846, Q29847, Q29848, Q29850, Q29851, Q29852, Q29854, Q29855, Q29857, Q29858, Q29861, Q29924, Q29925, Q29933, Q29935, Q29936, Q29940, Q29953, Q29961, Q29982, Q30173, Q30198, Q31603, Q31610, Q31612, Q31613, Q546L8, Q546M4, Q5JP37, Q5QT24, Q5RIP1, Q5SRJ2, Q5TK76, Q5TK77, Q860I4, Q861B5, Q8HWF0, Q8MGQ3, Q8MHN4, Q8SNC5, Q95343, Q95344, Q95365, Q95369, Q95392, Q95HA3, Q95HA8, Q95HM9, Q95IA6, Q95IB8, Q95IH5, Q95J00, Q96IT9, Q9BCM6, Q9BCM7, Q9BCM8, Q9BD06, Q9BD38, Q9BD43, Q9GIL3, Q9GIM3, Q9GIX1, Q9GIY5, Q9GIZ0, Q9GIZ9, Q9GJ00, Q9GJ17, Q9GJ20, Q9GJ23, Q9GJ31, Q9GJF0, Q9GJM7, Q9MX21, Q9MY37, Q9MY42, Q9MY43, Q9MY61, Q9MY75, Q9MY78, Q9MY79, Q9MY84, Q9MY92, Q9MY93, Q9MY94, Q9MYB8, Q9MYC3, Q9MYC7, Q9MYF4, Q9MYG1, Q9TP35, Q9TP36, Q9TP37, Q9TP95, Q9TPQ7, Q9TPQ9, Q9TPR2, Q9TPR4, Q9TPS6, Q9TPT2, Q9TPT4, Q9TPT6, Q9TPV2, Q9TQG1, Q9TQH3, Q9TQH6, Q9TQH7, Q9TQH8, Q9TQH9, Q9TQM2, Q9TQN4, Q9TQN6, Q9UQS8, Q9UQT0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityHost-virus interactionImmunityInnate immunity

Cellular component

Cell membraneEndoplasmic reticulumMembraneMHC I

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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