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Caspase-12 Antibody

CAT: 0800-R31215Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31215Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caspase-12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Caspase-12 attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of its expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q6UXS9
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 71-84 (KIFREHLWNSKKQL-human) were used as the immunogen for this Caspase-12 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Caspase-12 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Caspase-12 antibody is available for research use only.
Storage Conditions
After reconstitution, the Caspase-12 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Caspase-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Caspase-12 antibody; Lane 1: PANC; 2: SMMC-7721; 3: A549; 4: HeLa. Predicted molecular weight ~50/36~42kDa (pro/active) .

UniProtKB · Q6UXS9

Inactive caspase-12

CASPC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6UXS9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP12
Protein existence
2: Evidence at transcript level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-12
EC number
—
Processing
—
Secondary accessions
D6RBN7
Protein keywords

Coding sequence diversity

Alternative splicing

PTM

Phosphoprotein

Technical term

Reference proteome
Product Datasheet
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