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Caspase-3 Antibody

CAT: 0800-F52416-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F52416-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
P42574
Host
Mouse
Reactivity
Human
Immunogen
Purified His-tagged protein was used to produced this monoclonal Caspase-3 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
1262CT521.280.101
Applications
WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Caspase-3 antibody is available for research use only.
Storage Conditions
Aliquot the Caspase-3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Caspase-3 antibody western blot analysis in Jurkat, Ramos lysate

UniProtKB · P42574

Caspase-3

CASP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42574
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-3
EC number
3.4.22.56
Processing
Precursor
Secondary accessions
A8K5M2, D3DP53, Q96AN1, Q96KP2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinS-nitrosylationUbl conjugationZymogen

Biological process

Apoptosis

Cellular component

Cytoplasm

Molecular function

HydrolaseProteaseThiol protease
Product Datasheet
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