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EIF2S1 Antibody

CAT: 0800-R31138Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31138Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eukaryotic Translation Initiation Factor 2, Subunit 1, also called EIF2-alpha or EIF2A, is a protein that in humans is encoded by the EIF2S1 gene. Hartz (2010) mapped the gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37) . Ernst et al. (1987) stated that protein synthesis is inhibited due to phosphorylation of EIF2S1 in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2S1 phosphorylation and translational repression. Jacob et al. (1989) found that the alpha-Pal transcription factor bound to two palindromic sites within the EIF2S1 promoter and was essential for transcription of the gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL
UniProt
P05198
Host
Rabbit
Reactivity
Human
Immunogen
An amino acid sequence from the middle region of human Eukaryotic Translation Initiation Factor 2 subunit 1 (KDEQLESLFQRTAWV) was used as the immunogen for this EIF2A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the EIF2S1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This EIF2S1 antibody is available for research use only.
Storage Conditions
After reconstitution, the EIF2S1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the EIF2S1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of EIF2S1 antbody; Lane 1: COLO320; 2: CEM; 3: Raji; 4: HT1080 cell lysate. Predicted molecular weight: 36 kDa.
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