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ERBB4 Antibody (HER4)

CAT: 0800-R30981Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30981Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4, also known as HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. ERBB4 is a single-pass type I transmembrane protein with multiplefurin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and aPDZ domainbinding motif.Huang et al. (2000) reported that the proteinis enriched in the postsynaptic density and associates with PSD95. Itis a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al. (2001) concluded that gamma-secretase cleavage ofthe proteinmay represent another mechanism for receptor tyrosine kinase-mediated signaling.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q15303
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the N-terminus of human ErbB4/HER4 (KLSSLSDLEQQYRALRK) was used as the immunogen for this ERBB4 antibody (100% homologous in human, mouse and rat) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the ERBB4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ERBB4 antibody is available for research use only.
Storage Conditions
After reconstitution, the ERBB4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the ERBB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of ERBB4 antibody and Lane 1: human HeLa; 2: (h) U87; 3: mouse Neuro-2a cell lysate. Predicted molecular weight: 147-180kDa (precursor), 120, 80 kDa (cleaved forms) . Observed here at ~147kDa.
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