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HER-4 Antibody / ERBB4

CAT: 0800-V7741-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7741-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Immunofluorescence: 1-2 µg/mL
UniProt
Q15303
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 1116-1269) was used as the immunogen for the HER-4 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
HFR-1
Applications
FACS, IF
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the HER-4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HER-4 antibody is available for research use only.
Storage Conditions
Store the HER-4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the HER-4 antibody should be determined by the researcher.
Location
Cytoplasmic, plasma membrane, nuclear
Image Legend
Immunofluorescent staining of permeabilized human MCF7 cells with HER-4 antibody (clone HFR-1, green) and Reddot nuclear stain (red) .

UniProtKB · Q15303

Receptor tyrosine-protein kinase erbB-4

ERBB4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15303
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERBB4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B7ZLD7, B7ZLE2, B7ZLE3, Q2M1W1, Q59EW4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

ApoptosisLactationTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembraneMitochondrionNucleus

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

RepeatSignalTransmembraneTransmembrane helix

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