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ADAM17 Antibody

CAT: 0800-R30942Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30942Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADAM metallopeptidase domain 17, also called TACE (Tumor necrosis factor-alpha-converting enzyme), is an enzyme that belongs to the ADAM proteinfamily of disintegrins and metalloproteases. Expression studies showed that the encoded protein cleaves precursor tumor necrosis factor-alpha to its mature form. Northern blot analysis revealed that the gene was expressed as a 5-kb mRNA in all tissues examined. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha) at the surface of the cell, and from within theintracellular membranesof the trans-Golgi network. This process, which is also known as shedding, involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha), and is of known physiological importance. ADAM17 was the first sheddase to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.
CAS Number
9007-83-4
UniProt
P78536
Host
Rabbit
Immunogen
An amino acid sequence from the C-terminus of human ADAM17 (AASFKLQRQNRVDSKETEC) was used as the immunogen for this ADAM17 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
After reconstitution, the ADAM17 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ADAM17 antibody is available for research use only.
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