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ADAM10 Antibody

CAT: 0800-RQ7053Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7053Size:100 µg
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Description
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O14672
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids A217-D311) was used as the immunogen for the ADAM10 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the ADAM10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ADAM10 antibody is available for research use only.
Storage Conditions
After reconstitution, the ADAM10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ADAM10 antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of human U937 cells with ADAM10 antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= ADAM10 antibody.

UniProtKB · O14672

Disintegrin and metalloproteinase domain-containing protein 10

ADA10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14672
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADAM10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ADAM 10
EC number
3.4.24.81
Processing
Precursor
Secondary accessions
B4DU28, Q10742, Q92650
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoplasmic vesicleGolgi apparatusMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc

Biological process

Notch signaling pathway

Domain

SH3-bindingSignalTransmembraneTransmembrane helix

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