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Caspase-8 Antibody (large subunit)

CAT: 0800-R30825Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30825Size:100 µg
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Description
The human CASP8 gene, whose product is also known as Caspase-8 and FLICE, encodes an interleukin-1beta converting enzyme (ICE) -related cysteine protease that is activated by the engagement of several different death receptors. It is immediately recruited to the Fas receptor once it oligomerizes, and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex (DISC) . This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34. This region of human chromosome 2 was previously reported as the location of the CASP10 gene, whose product is closely related to CASP8. Caspase-8 deficiency in humans is compatible with normal development and shows that the enzyme has a postnatal role in immune activation of naive lymphocytes.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL (1), IHC (FFPE) : 0.5-1 µg/mL
UniProt
Q14790
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 257-277 (NNHNFAKAREKVPKLHSIRDR-human) was used as the immunogen for this Caspase-8 antibody. This sequence is from the large subunit.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Caspase-8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Caspase-8 antibody is available for research use only.
Storage Conditions
After reconstitution, the Caspase-8 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Image Legend
Western blot testing of Caspase-8 antibody (0.5ug/ml) and Lane 1: human A549; 2: (h) HeLa lysate. Predicted molecular weight: ~55 kDa (pro), ~40 kDa (large + small subunit), ~20 kDa (large subunit) .

UniProtKB · Q14790

Caspase-8

CASP8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14790
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-8
EC number
3.4.22.61
Processing
Precursor
Secondary accessions
O14676, Q14791, Q14792, Q14793, Q14794, Q14795, Q14796, Q15780, Q15806, Q53TT5, Q8TDI1, Q8TDI2, Q8TDI3, Q8TDI4, Q8TDI5, Q96T22, Q9C0K4, Q9UQ81
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinZymogen

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisHost-virus interaction

Cellular component

Cell projectionCytoplasmNucleus

Disease

Disease variant

Molecular function

HydrolaseProteaseThiol protease

Domain

Repeat

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