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Caspase-4 Antibody (large subunit)

CAT: 0800-F53383-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F53383-0.4MLSize:0.4 mL
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Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1.
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
P49662
Host
Rabbit
Reactivity
Human
Immunogen
This Caspase-4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 163-197 amino acids from the central region of human CASP4.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Caspase-4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Caspase-4 antibody is available for research use only.
Storage Conditions
Aliquot the Caspase-4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Caspase-4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Caspase-4 antibody at 1:2000 dilution + human Raji lysate; Expected molecular weight ~43 kDa (precursor), ~30 kDa (pro + large subunit), ~20 kDa (large subunit) .

UniProtKB · P49662

Caspase-4

CASP4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49662
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-4
EC number
3.4.22.57
Processing
Precursor
Secondary accessions
A2NHL8, A2NHL9, A2NHM0, B3KPZ9, B4DJH5, B4E2D2, O95601, Q7KYX7, Q9UG96
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinZymogen

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmEndoplasmic reticulumInflammasomeMembraneMitochondrionSecreted

Molecular function

HydrolaseProteaseThiol protease

Biological process

ImmunityInflammatory responseInnate immunityNecrosis

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