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Caspase-6 Antibody

CAT: 0800-R30513Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R30513Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease family. Using radiation hybrid mapping, the CASP6 gene was localized to human chromosome 4q25-q26. It functions as a downstream enzyme in the caspase activation cascade, and can cleave Lamin A to its signature apoptotic fragment.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, IHC (Frozen) : 0.5-1 µg/mL
UniProt
O35397
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Amino acids 7-27 (FYRSREVLDPAEQYKMDHKRR-rat) were used as the immunogen for this Caspase-6 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IHC-F
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Caspase-6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Caspase-6 antibody is available for research use only.
Storage Conditions
After reconstitution, the Caspase-6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting points. Titration of the Caspase-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic
Image Legend
Western blot testing of Caspase-6 antibody and Lane 1: rat liver; 2: rat kidney; 3: rat testis; 4: NRK; 5: mouse liver; 6: mouse kidney; 7: mouse testis tissue lysate. Predicted molecular weight: ~33 kDa (precursor) .

UniProtKB · O35397

Caspase-6

CASP6_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
O35397
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Casp6
Protein existence
2: Evidence at transcript level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
CASP-6
EC number
3.4.22.59
Processing
Precursor
Secondary accessions
—
Protein keywords

Biological process

Apoptosis

PTM

Autocatalytic cleavageLipoproteinPalmitatePhosphoproteinZymogen

Cellular component

CytoplasmNucleus

Molecular function

HydrolaseProteaseThiol protease

Technical term

Reference proteome

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