MAP2K2 Antibody / MEK2

• Description:

  MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

• Specifications:

  Immunohistochemistry (FFPE) : 1:10-1:50, Western blot: 1:500-1:1000

• UniProt:

  P36507

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 200-229 from the human protein was used as the immunogen for the MAP2K2 antibody.

• Clonality:

  Polyclonal

• Isotype:

  Ig

• Applications:

  IHC-P, WB

• Purity:

  Antigen affinity purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the MAP2K2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This MAP2K2 antibody is available for research use only.

• Storage Conditions:

  Aliquot the MAP2K2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  The stated application concentrations are suggested starting points. Titration of the MAP2K2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Location:

  Cytoplasmic

• Image Legend:

  Western blot testing of human 1) HeLa and 2) MOLT4 cell lysate with MAP2K2 antibody. Expected molecular weight: 45-50 kDa.