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Phospho-CDC25A Antibody (pS124)

CAT: 0800-F54292-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F54292-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Immunohistochemistry (FFPE) : 1:25
UniProt
P30304
Host
Rabbit
Reactivity
Human
Immunogen
The amino acids surrounding phosphorylated serine 124 from the human protein were used as the immunogen for the phospho-CDC25A antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the phospho-CDC25A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This phospho-CDC25A antibody is available for research use only.
Storage Conditions
Aliquot the phospho-CDC25A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the phospho-CDC25A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of lysate from human A2780 cells untreated or treated with alkaline phosphatase using phospho-CDC25A antibody. Predicted molecular weight: 59-70 kDa.

UniProtKB · P30304

M-phase inducer phosphatase 1

MPIP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P30304
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDC25A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.48
Processing
—
Secondary accessions
Q8IZH5, Q96IL3, Q9H2F2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleCell divisionMitosis

Molecular function

HydrolaseProtein phosphatase

PTM

PhosphoproteinUbl conjugation

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