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HtrA2 Antibody

CAT: 0800-F54031-0.1MLSize: 0.1 mLDry Ice: NoHazardous: No
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CAT#:0800-F54031-0.1MLSize:0.1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:500, Immunoprecipitation: suitable
UniProt
O43464
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant protein was used as the immunogen for this HtrA2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
8G11-4B8-4F10-G5
Applications
WB, IP
Purity
Protein G affinity
Format
Purified
Buffer
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Reconstitution
Store the HtrA2 antibody at -20oC.
Limitations
This HtrA2 antibody is available for research use only.
Storage Conditions
Store the HtrA2 antibody at -20°C.
Formulation
In PBS with 50% glycerol and 0.03% ProClin 300
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HtrA2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of human 293T cell lysate with HtrA2 antibody at 1:500. Predicted molecular weight: 38-49 kDa.

UniProtKB · O43464

Serine protease HTRA2, mitochondrial

HTRA2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43464
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTRA2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.108
Processing
Precursor
Secondary accessions
Q9HBZ4, Q9P0Y3, Q9P0Y4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

PTM

Autocatalytic cleavageUbl conjugationZymogen

Disease

Disease variantEpilepsyNeurodegenerationParkinson diseaseParkinsonism

Cellular component

Endoplasmic reticulumMembraneMitochondrion

Molecular function

HydrolaseProteaseSerine protease

Domain

Transit peptideTransmembraneTransmembrane helix

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