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HtrA3 Antibody

CAT: 0800-F54667-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F54667-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1:25, Western blot: 1:500-1:2000
UniProt
P83110
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A portion of amino acids 112-144 from the human protein was used as the immunogen for the HtrA3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the HtrA3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This HtrA3 antibody is available for research use only.
Storage Conditions
Aliquot the HtrA3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the HtrA3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of rat testis lysate with HtrA3 antibody. Predicted molecular weight ~49 kDa.

UniProtKB · P83110

Serine protease HTRA3

HTRA3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P83110
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HTRA3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.-
Processing
Precursor
Secondary accessions
Q7Z7A2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bond

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

Domain

Signal
Product Datasheet
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