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Dnmt3a Antibody

CAT: 0800-F53021-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F53021-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
Q9Y6K1
Host
Rabbit
Reactivity
Human
Immunogen
This Dnmt3a antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 463-497 amino acids from the central region of human Dnmt3a.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dnmt3a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dnmt3a antibody is available for research use only.
Storage Conditions
Aliquot the Dnmt3a antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Chicken, Mouse, Rat
Image Legend
Western blot analysis of lysate from (1) HeLa cell line and (2) human skeletal muscle tissue using Dnmt3a antibody at 1:1000. Predicted molecular weight: 100-130 kDa

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