DNMT3L Antibody

CAT: 0800-RQ6940Size: 100 µgDry Ice: NoHazardous: No
CAT#:0800-RQ6940Size:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DNA (cytosine-5) -methyltransferase 3-like is an enzyme that in humans is encoded by the DNMT3L gene. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9UJW3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human DNMT3L protein (amino acids M1-L386) was used as the immunogen for the DNMT3L antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the DNMT3L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This DNMT3L antibody is available for research use only.
Storage Conditions
After reconstitution, the DNMT3L antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the DNMT3L antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) rat testis, 2) rat kidney, 3) mouse testis and 4) mouse kidney tissue lysate with DNMT3L antibody. Predicted molecular weight ~49 kDa.

Related Products

CatalogName
RQ7164DNMT3B Antibody
F44638-0.08MLDnmt3a Antibody
F40558-0.4MLDnmt3a Antibody
F40603-0.08MLDnmt3a Antibody
F44638-0.4MLDnmt3a Antibody
V3827SAF-100UGDnmt3a Antibody
V3827-20UGDnmt3a Antibody
F40603-0.4MLDnmt3a Antibody
RQ6614Dnmt3b Antibody
F40611-0.08MLDnmt3b Antibody

Alternative Products

CatalogName
MBS2519336-01DNMT3L Antibody

Popular Products