Cdk4 Antibody

CAT: 0800-F52368-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
CAT#:0800-F52368-0.08MLSize:0.08 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity) .
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:25, Immunofluorescence: 1:25
UniProt
P35426
Host
Rabbit
Reactivity
Human, Rat
Immunogen
A portion of amino acids 272-303 from the rat protein was used as the immunogen for this Cdk4 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, IF, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Cdk4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Cdk4 antibody is available for research use only.
Storage Conditions
Aliquot the Cdk4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Cdk4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Nuclear and cytoplasmic
Image Legend
IHC testing of paraffin-embedded rat small intestine using Cdk4 antibody at 1:25.

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