PAK1 Antibody
CAT:
800-F50890-0.08ML
Size:
0.08 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PAK1 Antibody
- Description: PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42/p21. Structurally, the PAK1 contains 1 CRIB domain.
- CAS Number: 9007-83-4
- UniProt: Q13153
- Host: Rabbit
- Immunogen: A portion of amino acids 401-430 from the human protein was used as the immunogen for this PAK1 antibody.
- Clonality: Polyclonal
- Isotype: Ig
- Applications: WB, IF, IHC, ELISA
- Format: Antigen affinity purified
- Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
- Reconstitution: Aliquot the PAK1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
- Limitations: This PAK1 antibody is available for research use only.