PAK6 Antibody

• Description :

  The PAK6 protein shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

• CAS Number :

  9007-83-4

• Specifications :

  Western blot: 1:1000

• UniProt :

  Q9NQU5

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  A portion of amino acids 116-146 from the human protein was used as the immunogen for this PAK6 antibody.

• Clonality :

  Polyclonal

• Isotype :

  Ig

• Applications :

  WB, ELISA

• Purity :

  Purified

• Format :

  Purified

• Buffer :

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution :

  Aliquot the PAK6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations :

  This PAK6 antibody is available for research use only.

• Storage Conditions :

  Aliquot the PAK6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation :

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes :

  Titration of the PAK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• Image Legend :

  Western blot analysis of PAK6 antibody in lysate from transiently transfected COS7 cells. Lane 1: negative control, 2: PAK1, 3: PAK2, 4: PAK4, 5: PAK5, and 6: PAK6-expressing cells.