DDR1 Antibody

DDR1 Antibody

• Description: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
• CAS Number: 9007-83-4
• UniProt: Q08345
• Host: Rabbit
• Immunogen: A portion of amino acids 299-330 from the human protein was used as the immunogen for this DDR1 antibody.
• Clonality: Polyclonal
• Isotype: Ig
• Applications: WB, IHC, IF, FACS, ELISA
• Format: Purified
• Buffer: In 1X PBS, pH 7.4, with 0.09% sodium azide
• Reconstitution: Aliquot the DDR1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
• Limitations: This DDR1 antibody is available for research use only.