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DDR2 Antibody (TYRO10)

CAT: 0800-F50688-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50688-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DDR2/TYRO10 is a tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50, Flow Cytometry: 1:10-1:50
UniProt
Q16832
Host
Rabbit
Reactivity
Human
Immunogen
This DDR2 antibody was produced from rabbits immunized with a his tag recombinant protein of human DDR2/TYRO10.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, FACS, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the DDR2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This DDR2 antibody is available for research use only.
Storage Conditions
Aliquot the DDR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the DDR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
IHC analysis of FFPE human normal lung with DDR2 antibody

UniProtKB · Q16832

Discoidin domain-containing receptor 2

DDR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16832
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DDR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Discoidin domain receptor 2
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q7Z730
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Disease

Disease variantDwarfism

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Biological process

Osteogenesis

Domain

SignalTransmembraneTransmembrane helix

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