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SIRT5 Antibody

CAT: 0800-F49521-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F49521-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. [UniProt]
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Western blot: 1:1000
UniProt
Q9NXA8
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 263-292 from the human protein was used as the immunogen for this SIRT5 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the SIRT5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SIRT5 antibody is available for research use only.
Storage Conditions
Aliquot the SIRT5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the SIRT5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of SIRT5 antibody in Jurkat lysate

UniProtKB · Q9NXA8

NAD-dependent protein deacylase sirtuin-5, mitochondrial

SIR5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NXA8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIRT5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.-
Processing
Precursor
Secondary accessions
B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9Y6E6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMitochondrionNucleus

Ligand

Metal-bindingNADZinc

Molecular function

Transferase

Domain

Transit peptide

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