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SIRT3 Antibody

CAT: 0800-F49520-0.05MLSize: 0.05 mLDry Ice: NoHazardous: No
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CAT#:0800-F49520-0.05MLSize:0.05 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT3 is an NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
Q8R104
Host
Rabbit
Reactivity
Human, Mouse, Hamster
Immunogen
A portion of amino acids 304-334 from the mouse protein was used as the immunogen for this SIRT3 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Store at 4oC for up to one month. For long term, aliquot the SIRT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SIRT3 antibody is available for research use only.
Storage Conditions
Store at 4°C for up to one month. For long term, aliquot the SIRT3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
The stated application concentrations are suggested starting points. Titration of the SIRT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of lysate from mouse heart tissue lysate using SIRT3 antibody diluted at 1:1000.

UniProtKB · Q8R104

NAD-dependent protein deacetylase sirtuin-3

SIR3_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q8R104
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Sirt3
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.3.1.286
Processing
Precursor
Secondary accessions
B9W0A9, C6ZII7, Q9EPA8
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMitochondrion

Ligand

Metal-bindingNADZinc

Technical term

Reference proteome

Molecular function

Transferase

Domain

Transit peptide

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