Products for Research Use Only
RegisterLogin

ADAM17 Antibody

CAT: 0800-F44301-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-F44301-0.08MLSize:0.08 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in the proteolytic processing of ACE2. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1:1000
UniProt
P78536
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 794-823 from the human protein was used as the immunogen for this ADAM17 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the ADAM17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ADAM17 antibody is available for research use only.
Storage Conditions
Aliquot the ADAM17 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot analysis of ADAM17 antibody and Jurkat lysate. Expected molecular weight: 80-130KD depending on level of glycosylation

UniProtKB · P78536

Disintegrin and metalloproteinase domain-containing protein 17

ADA17_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P78536
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ADAM17
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ADAM 17
EC number
3.4.24.86
Processing
Precursor
Secondary accessions
O60226
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinUbl conjugationZymogen

Disease

Disease variantHypotrichosis

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc

Biological process

Notch signaling pathway

Domain

SH3-bindingSignalTransmembraneTransmembrane helix

Related Products

CatalogName
R30611ADAM10 Antibody
RQ4703ADAM10 Antibody
R34477-100UGADAM19 Antibody
R31181ADAM19 Antibody
R33112-100UGADAM12 Antibody
R35585-100UGADAM12 Antibody
RQ6033ADAM15 Antibody
RQ7053ADAM10 Antibody
RQ4035ADAM10 Antibody
R33315-100UGADAM33 Antibody

Alternative Products

CatalogName
GTR18075576-01ADAM17 Antibody

Popular Products