Caspase-3 Antibody

CAT: 0800-F41376-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No

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CAT#:0800-F41376-0.08MLSize:0.08 mL

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Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].

CAS Number

9007-83-4

UniProt

P42574

Host

Rabbit

Immunogen

A portion of amino acids 219-248 from the human protein was used as the immunogen for this Caspase-3 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC, FACS, ELISA

Format

Purified

Buffer

In 1X PBS pH 7.4 with 0.09% sodium azide

Reconstitution

Aliquot the Caspase-3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Caspase-3 antibody is available for research use only.

UniProtKB · P42574

Caspase-3

CASP3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P42574
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CASP3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CASP-3
EC number: 3.4.22.56
Processing: Precursor
Secondary accessions: A8K5M2, D3DP53, Q96AN1, Q96KP2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinS-nitrosylationUbl conjugationZymogen

Biological process

Apoptosis

Cellular component

Cytoplasm

Molecular function

HydrolaseProteaseThiol protease

Product Datasheet

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Alternative Products

Catalog	Name
70R-31077	Caspase 3 antibody
GWB-E8FE05	CASPASE-3 Antibody