Caspase-5 Antibody

CAT: 0800-F41059-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No

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CAT#:0800-F41059-0.4MLSize:0.4 mL

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Description

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

CAS Number

9007-83-4

UniProt

P51878

Host

Rabbit

Immunogen

A portion of amino acids 162-191 from the human protein was used as the immunogen for this Caspase-5 antibody.

Clonality

Polyclonal

Isotype

Applications

WB, IHC, FACS, ELISA

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the Caspase-5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Caspase-5 antibody is available for research use only.

UniProtKB · P51878

Caspase-5

CASP5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P51878
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CASP5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CASP-5
EC number: 3.4.22.58
Processing: Precursor
Secondary accessions: B4DKP5, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6, Q1HBJ3, Q6DJV7

Protein keywords

Coding sequence diversity

Alternative initiationAlternative splicing

Biological process

Apoptosis

Molecular function

HydrolaseProteaseThiol protease

Technical term

Proteomics identificationReference proteome

PTM

Zymogen

Product Datasheet

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