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CD11b Antibody / MAC-1 / ITGAM

CAT: 0800-F40833-0.08MLSize: 0.08 mLDry Ice: NoHazardous: No
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CAT#:0800-F40833-0.08MLSize:0.08 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD11b is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
CAS Number
9007-83-4
Specifications
IHC (Paraffin) : 1:50-1:100, Flow Cytometry: 1:10-1:50, Western blot: 1:1000
UniProt
P11215
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 253-282 from the human protein was used as the immunogen for this CD11b antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, FACS, WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the CD11b antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD11b antibody is available for research use only.
Storage Conditions
Aliquot the CD11b antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the CD11b antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cell membrane, cytoplasm
Image Legend
Western blot testing of human spleen lysate with CD11b antibody. Expected molecular weight: 128-170 kDa depending on glycosylation level.

UniProtKB · P11215

Integrin alpha-M

ITAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11215
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q4VAK0, Q4VAK1, Q4VAK2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionImmunityInnate immunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Disease

Systemic lupus erythematosus
Product Datasheet
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