ES-8891

CAT: 0804-HY-117913Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117913Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis[1].
CAS Number
[129445-88-1]
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/es-8891.html
Smiles
O=C(NCCCCCC)C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(CN1CCOCC1)=O)CC2=C3C=CC=CC3=CC=C2)=O)CC4=CSC=N4)=O)CC5CCCCC5
Molecular Formula
C42H60N6O6S
Molecular Weight
777.03
References & Citations
[1]YUTAKA KITAMI, KUNIO HIWADA, EIKI MURAKAMI, TAKERU IWATA, SHINJIRO MUNETA AND TATSUO KOKUBU"
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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