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ES 936

CAT: 0804-HY-100367-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100367-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ES 936 is a potent and specific NQO1 inhibitor. ES 936 inhibits the growth of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 108 nM and 365 nM, respectively. ES936 significantly inhitbits the growth rate of MIA PaCa-2 xenograft tumors in mice. ES 936 can be used for the study of pancreatic cancer[1][2][3].
CAS Number
[192820-78-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/es-936.html
Purity
98.66
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C(C(OC)=C1)C2=C(N(C)C(C)=C2COC3=CC=C([N+]([O-])=O)C=C3)C1=O
Molecular Formula
C18H16N2O6
Molecular Weight
356.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Dehn DL, et al. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol. 2003 Sep;64 (3) :714-20. |[2]Dehn DL, et al. 5-Methoxy-1,2-dimethyl-3-[ (4-nitrophenoxy) methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. |[3]Zhou H, et al. NAD (P) H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul;334 (1) :260-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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