ES 936

• Description :

  ES 936 is a potent and specific NQO1 inhibitor. ES 936 inhibits the growth of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 108 nM and 365 nM, respectively. ES936 significantly inhitbits the growth rate of MIA PaCa-2 xenograft tumors in mice. ES 936 can be used for the study of pancreatic cancer[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  NF-κB; Quinone Reductase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/es-936.html

• Purity :

  98.66

• Solubility :

  DMSO : 2 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C(OC)=C1)C2=C(N(C)C(C)=C2COC3=CC=C([N+]([O-])=O)C=C3)C1=O

• Molecular Formula :

  C18H16N2O6

• Molecular Weight :

  356.33

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Dehn DL, et al. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol. 2003 Sep;64 (3) :714-20. |[2]Dehn DL, et al. 5-Methoxy-1,2-dimethyl-3-[ (4-nitrophenoxy) methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. |[3]Zhou H, et al. NAD (P) H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul;334 (1) :260-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [192820-78-3]