ES 6864

• UNSPSC Description:

  ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].

• Target Antigen:

  Renin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/es-6864.html

• Smiles:

  O=C(N1CCOCC1)C[C@H](C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@@H](O)CC(NCCN3CCOCC3)=O)=O)CC4=CSC=N4)=O)CC5=CC=CC6=C5C=CC=C6

• Molecular Weight:

  791.01

• References & Citations:

  [1]Hiwada K, et al., A highly potent and long-acting oral inhibitor of human renin. Hypertension. 1988 Jun;11(6 Pt 2):708-12.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  116326-39-7