ES 6864

• Description :

  ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets[1].

• UNSPSC :

  12352005

• Target :

  Renin

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/es-6864.html

• Smiles :

  O=C(N1CCOCC1)C[C@H](C(N[C@H](C(N[C@@H](CC2CCCCC2)[C@@H](O)CC(NCCN3CCOCC3)=O)=O)CC4=CSC=N4)=O)CC5=CC=CC6=C5C=CC=C6

• Molecular Formula :

  C42H58N6O7S

• Molecular Weight :

  791.01

• References & Citations :

  [1]Hiwada K, et al., A highly potent and long-acting oral inhibitor of human renin. Hypertension. 1988 Jun;11 (6 Pt 2) :708-12.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [116326-39-7]