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NSC-88915

CAT: 0804-HY-124486Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124486Size:1 Each
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Description
NSC-88915 is an inhibitor of Tdp1 with an IC50 of 7.7 μM. NSC-88915 is a C21-subsitited progesterone derivative[1][2].
CAS Number
21170-34-3
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Smiles
O=S(C1=CC=C(C=C1)Br)(OCC([C@H]2CC[C@]3([C@@]4(CCC5=CC(CC[C@@]5([C@]4(CC[C@]23C)[H])C)=O)[H])[H])=O)=O
Molecular Formula
C27H33BrO5S
Molecular Weight
549.52
References & Citations
[1]Dexheimer, T. S., et al., (2009) . 4-Pregnen-21-ol-3,20-dione-21- (4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors. Journal of medicinal chemistry, 52 (22), 7122-7131.|[2]Nguyen, T. X., et al., (2012) . Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1) -topoisomerase I (Top1) inhibitors. Journal of medicinal chemistry, 55 (9), 4457-4478.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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