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Lenalidomide-4-aminomethyl

CAT: 0804-HY-138882Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-138882Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
CAS Number
790652-68-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-4-aminomethyl.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N(CC1=C2C=CC=C1CN)C2=O)CC3)NC3=O
Molecular Formula
C14H15N3O3
Molecular Weight
273.29
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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