Lenalidomide-5-aminomethyl

Lenalidomide-5-aminomethyl

• CAS Number: 1010100-28-3
• UNSPSC Description: Lenalidomide-5-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].
• Target Antigen: Ligands for E3 Ligase
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lenalidomide-5-aminomethyl.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(N(CC1=C2C=CC(CN)=C1)C2=O)CC3)NC3=O
• Molecular Weight: 273.29
• References & Citations: [1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported