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PEG2000-C-DMG

CAT: 0804-HY-145411-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-145411-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA[1][2].
CAS Number
1443687-74-8
UNSPSC
12352211
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/peg2000-c-dmg.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCCCC(O[C@@H](COC(NCCCOCCOC)=O)COC(CCCCCCCCCCCCC)=O)=O.[45]
Molecular Formula
C126H249NO52
Molecular Weight
2610.29
References & Citations
[1]Garber K. Alnylam launches era of RNAi drugs. Nat Biotechnol. 2018;36 (9) :777-778. |[2]Adams D, Gonzalez-Duarte A, O'Riordan WD, et al. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018;379 (1) :11-21.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

Chemical Information

Peg(2000)-C-dmg
CAS Number1443687-74-8
PubChem CID166638297
IUPAC Name[(2R)-3-[3-(2-methoxyethoxy)propylcarbamoyloxy]-2-tetradecanoyloxypropyl] tetradecanoate
Molecular FormulaC38H73NO8
Molecular Weight672.0
XLogP12.3
Topological Polar Surface Area109
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count39
Heavy Atom Count47
Formal Charge0
Complexity705
SMILES
CCCCCCCCCCCCCC(=O)OC[C@H](COC(=O)NCCCOCCOC)OC(=O)CCCCCCCCCCCCC
InChI
InChI=1S/C38H73NO8/c1-4-6-8-10-12-14-16-18-20-22-24-27-36(40)45-33-35(34-46-38(42)39-29-26-30-44-32-31-43-3)47-37(41)28-25-23-21-19-17-15-13-11-9-7-5-2/h35H,4-34H2,1-3H3,(H,39,42)/t35-/m1/s1
InChIKey
YWYMLVACUCXAEC-PGUFJCEWSA-N
Chemical Structure
2D Structure
2D structure of Peg(2000)-C-dmg
CAS: 1443687-74-8
CID: 166638297
Formula: C38H73NO8
MW: 672.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight672.0
XLogP312.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count39
Exact Mass671.53361829
Monoisotopic Mass671.53361829
Topological Polar Surface Area109 Ų
Heavy Atom Count47
Formal Charge0
Complexity705
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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