PEG2000-C-DMG

• Description :

  PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA[1][2].

• UNSPSC :

  12352211

• Target :

  Liposome

• Type :

  Oligonucleotides

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/peg2000-c-dmg.html

• Purity :

  99.97

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCCCCCCCC(O[C@@H](COC(NCCCOCCOC)=O)COC(CCCCCCCCCCCCC)=O)=O.[45]

• Molecular Formula :

  C126H249NO52

• Molecular Weight :

  2610.29

• References & Citations :

  [1]Garber K. Alnylam launches era of RNAi drugs. Nat Biotechnol. 2018;36 (9) :777-778. |[2]Adams D, Gonzalez-Duarte A, O'Riordan WD, et al. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018;379 (1) :11-21.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Oligonucleotides

• Clinical Information :

  No Development Reported

• CAS Number :

  [1443687-74-8]