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Methoxy-SANT-2

CAT: 0804-HY-122017Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122017Size:1 Each
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Description
Methoxy-SANT-2 (TC-132) is a potent hedgehog antagonist with an IC50 value of 79.8 nM. Methoxy-SANT-2 inhibits the Gli1 reporter gene expression. Methoxy-SANT-2 has the potential for the research of cancer[1].
CAS Number
496793-78-3
Product Name Alternative
TC-132
UNSPSC
12352005
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/methoxy-sant-2.html
Smiles
COC1=C(C(OC)=CC(C(NC2=CC(C3=NC4=C(N3)C=CC=C4)=C(C=C2)Cl)=O)=C1)OC
Molecular Formula
C23H20ClN3O4
Molecular Weight
437.88
References & Citations
[1]Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17 (14) :4943-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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