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LY 344864

CAT: 0804-HY-13788-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13788-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY 344864 is a selective, orally active 5-HT1F receptor agonist with a Ki of 6 nM. LY 344864 is a full agonist producing an effect similar in magnitude to serotonin itself. LY 344864 can cross the blood brain barrier to some extent[1].
CAS Number
186544-26-3
UNSPSC
12352005
Hazard Statement
H317, H319
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly-344864.html
Concentration
10mM
Purity
98.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC2=C(NC3=C2C[C@H](N(C)C)CC3)C=C1)C4=CC=C(F)C=C4
Molecular Formula
C21H22FN3O
Molecular Weight
351.42
Precautions
H317, H319
References & Citations
[1]Phebus LA, Johnson KW, Zgombick JM, Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brainpenetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 1997;61 (21) :2117-26.|[2]Scholpa NE, et al. 5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease. Br J Pharmacol. 2018 Jan;175 (2) :348-358.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; lactoferrin; mLAG-3; MUC3; α adrenergic receptor; α-1 microglobulin

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Alternative Products

CatalogName
A3569-5.1LY 344864
MBS5802843LY 344864 hydrochloride
A15148-50LY 344864 50mg
A15148-25LY 344864 25mg
GTR19200748-01LY 344864 racemate
TRC-L486400-100MGLY-344864 Hydrochloride
A15148-5LY 344864 5mg
A15148-2LY 344864 2mg
T11902-01LY 344864 S-enantiomer
A21748-1LY 344864 hydrochloride 1mg

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