10074-G5

• Description:

  10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H319, H335

• Target:

  Autophagy; c-Myc

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/10074-G5.html

• Purity:

  99.63

• Solubility:

  DMSO : ≥ 28 mg/mL

• Smiles:

  O=[N+] ([O-]) C1=CC=C (NC2=CC=CC=C2C3=CC=CC=C3) C4=NON=C41

• Molecular Formula:

  C18H12N4O3

• Molecular Weight:

  332.31

• Precautions:

  H301, H315, H319, H335

• References & Citations:

  [1]Clausen DM, et al. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization. J Pharmacol Exp Ther. 2010 Dec;335 (3) :715-27.|[2]Chauhan J, et al. Discovery of methyl 4'-methyl-5- (7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) -[1,1'-biphenyl]-3-carboxylate, an improved small-molecule inhibitor of c-Myc-max dimerization. ChemMedChem. 2014 Oct;9 (10) :2274-85.|[3]Yap JL, et al. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem Lett. 2013 Jan 1;23 (1) :370-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  413611-93-5