KSP-1007

• Description :

  KSP-1007 is a bicyclic boronate-based broad-spectrum β-lactamase inhibitor. KSP-1007 can effectively inhibit class A, B, C and D β-lactamases, including serine-type, metallo-type (such as NDM, VIM, IMP) and Acinetobacter baumannii OXA-type enzymes. KSP-1007 can enhance the antibacterial activity of Meropenem (HY-13678), reduce its MIC value, and be effective against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. KSP-1007 can be used for the research of bacterial infection[1].

• UNSPSC :

  12352005

• Target :

  Bacterial; Beta-lactamase

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  OC(C1=C2C(CCB(O2)O)=CC=C1OC3CN(C3)C([C@@H](C4=CN=CN4)N)=O)=O

• Molecular Formula :

  C17H19BN4O6

• Molecular Weight :

  386.17

• References & Citations :

  [1]Takemoto K, et al. In vitro and in vivo activities of KSP-1007, a broad-spectrum inhibitor of serine- and metallo-β-lactamases, in combination with meropenem against carbapenem-resistant Gram-negative bacteria. Antimicrob Agents Chemother. 2024 Jun 5;68 (6) :e0160223.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2380240-20-8]