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Liothyronine (sodium)

CAT: 0804-HY-A0070-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0070-01Size:100 mg
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Description
Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].
CAS Number
55-06-1
Product Name Alternative
Triiodothyronine (sodium) ; 3,3',5-Triiodo-L-thyronine (sodium) ; T3 (sodium)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/3,3_acute_,5-Triiodo-L-thyronine-sodium.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O
Molecular Formula
C15H11I3NNaO4
Molecular Weight
672.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
BioRxiv. 2024 November 15.|BMC Biol. 2025 Apr 24;23 (1) :107.|J Adv Res. 2025 Apr 19:S2090-1232 (25) 00273-5.|J Ethnopharmacol. 2022 Nov 15:298:115622.|JCI Insight. 2021 Jun 22;6 (12) :e142838.|Nat Cell Biol. 2025 Oct 15.|Sci Adv. 2024 Feb 9;10 (6) :eadk3931.|Acta Pharmacol Sin. 2024 May 24.|Adipocyte. 2022 Dec;11 (1) :84-98.|Adv Healthc Mater. 2025 Apr;14 (9) :e2404388.|Adv Sci (Weinh) . 2025 Nov 9:e08571.|Am J Physiol Endocrinol Metab. 2024 May 1;326 (5) :E696-E708.|bioRxiv. 2025 Oct 14.|Cell Death Discov. 2022 Apr 30;8 (1) :236.|Cell Metab. 2023 Nov 7;35 (11) :1915-1930.e8.|Cell Rep. 2024 Mar 18;43 (3) :113930.|Chem Eng J. 2024 Sep 15.|Drug Metab Dispos. 2025 Sep 23.|Environ Sci Technol. 2025 Mar 11;59 (9) :4530-4539.|Eur J Med Chem. 2024 Apr 5:269:116344.|Food Science and Human Wellness. 2023 Nov;12 (6) ;2061-2072.|J Hazard Mater. 2025 Mar 29:492:138085.|J Med Chem. 2022 Feb 10;65 (3) :2571-2592.|J Nutr Biochem. 2020 Apr;78:108335.|J Therm Biol. 2024 Jul 2:123:103906.|Methods Mol Biol. 2023:2683:103-111.|Mol Metab. 2024 Oct 29:102053.|Mol Metab. 2025 May:95:102125.|Nat Commun. 2023 Jun 2;14 (1) :3208.|Nat Commun. 2025 Aug 11;16 (1) :7414.|Patent. US20220389379A1.|Phytomedicine. 2025 Oct 11:148:157400.|Redox Biol. 2025 Sep:85:103751.|Sci Rep. 2024 Sep 2;14 (1) :20370.

Chemical Information

Liothyronine Sodium

Liothyronine sodium is the sodium salt of liothyronine. Thought to be more active than levothyroxine and with a rapid (few hours) onset and short duration of action, liothyronine sodium is used in the treatment of hypothyroidism, particularly in cases of hypothyroid coma. It contains a 3,3',5-triiodo-L-thyroninate.

CAS Number55-06-1
PubChem CID23666110
IUPAC Namesodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
Molecular FormulaC15H11I3NNaO4
Molecular Weight672.95
Topological Polar Surface Area95.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity408
SMILES
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])N)I)I)O.[Na+]
InChI
InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
InChIKey
SBXXSUDPJJJJLC-YDALLXLXSA-M
Chemical Structure
2D Structure
2D structure of Liothyronine Sodium
CAS: 55-06-1
CID: 23666110
Formula: C15H11I3NNaO4
MW: 672.95
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight672.95
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass672.7720
Monoisotopic Mass672.7720
Topological Polar Surface Area95.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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A20353-200Liothyronine sodium 200mg
A20353-100Liothyronine sodium 100mg
A20353-500Liothyronine sodium 500mg
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