Liothyronine (sodium)

• UNSPSC Description:

  Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

• Target Antigen:

  Endogenous Metabolite; Thyroid Hormone Receptor

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/3,3_acute_,5-Triiodo-L-thyronine-sodium.html

• Purity:

  99.49

• Solubility:

  0.1 M NaOH : 12.5 mg/mL (ultrasonic;adjust pH to 11 with NaOH)|DMSO : 5.56 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  N[C@@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O)C(I)=C2)C(O[Na])=O

• Molecular Weight:

  672.96

• References & Citations:

  [1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.bioRxiv. 2024 November 15.|J Ethnopharmacol. 2022 Aug 11;115622.|JCI Insight. 2021 Jun 22;6(12):142838.|Sci Adv. 2024 Feb 9;10(6):eadk3931.|Acta Pharmacol Sin. 2024 May 24.|Adipocyte. 2022 Dec;11(1):84-98.|Am J Physiol Endocrinol Metab. 2024 Apr 3.|Cell Death Discov. 2022 Apr 30;8(1):236.|Cell Metab. 2023 Sep 7;S1550-4131(23)00304-2.|Cell Rep. 2024 Mar 18;43(3):113930.|Chem Eng J. 2024 Sep 15.|Eur J Med Chem. 2024 Mar 20:269:116344.|Food Science and Human Wellness. 2023 Nov;12(6);2061-2072.|J Med Chem. 2022 Jan 21.|J Nutr Biochem. 2020 Apr;78:108335.|J Therm Biol. 2024 Jul 2:123:103906.|Methods Mol Biol. 2023;2683:103-111.|Mol Metab. 2024 Oct 29:102053.|Nat Commun. 2023 Jun 2;14(1):3208.|Patent. US20220389379A1.|Sci Rep. 2024 Sep 2;14(1):20370.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  55-06-1