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Liothyronine-d4

CAT: 0804-HY-A0070AS5Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0070AS5Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Liothyronine-d4 (Triiodothyronine-d4) is the deuterium labeled Liothyronine. Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with vs of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR[1][2][3].
Product Name Alternative
Triiodothyronine-d4; 3,3',5-Triiodo-L-thyronine-d4; T3-d4
UNSPSC
12352101
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Thyroid Hormone Receptor
Related Pathways
Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Endocrinology
Smiles
O=C(O[2H])[C@H](CC1=CC(I)=C(C(I)=C1)OC2=CC=C(O[2H])C(I)=C2)N([2H])[2H]
Molecular Formula
C15H8D4I3NO4
Molecular Weight
655.00
References & Citations
[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94. |[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92. |[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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