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Liothyronine

CAT: 0804-HY-A0070A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-A0070A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with Kis of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR[1][2][3].
CAS Number
6893-02-3
Product Name Alternative
Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Thyroid Hormone Receptor
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/3,3_acute_,5-Triiodo-L-thyronine.html
Purity
99.82
Solubility
1M NaOH : 50 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C=C(C=C1)OC2=C(C=C(C=C2I)C[C@@H](C(O)=O)N)I)I
Molecular Formula
C15H12I3NO4
Molecular Weight
650.97
Precautions
H302, H315, H319, H335
References & Citations
[1]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85 (2) :189-94.|[2]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195 (1) :385-92.|[3]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20 (11) :3622-34.|[4]Zhou X, et al. Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR. Cell Commun Signal. 2020 Sep 7;18 (1) :142.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Citation 01
Acta Pharmacol Sin. 2024 May 24.|Adipocyte. 2022 Dec;11 (1) :84-98.|Adv Healthc Mater. 2025 Apr;14 (9) :e2404388.|Adv Sci (Weinh) . 2025 Nov 9:e08571.|Am J Physiol Endocrinol Metab. 2024 May 1;326 (5) :E696-E708.|bioRxiv. 2025 Oct 14.|Cell Death Discov. 2022 Apr 30;8 (1) :236.|Cell Metab. 2023 Nov 7;35 (11) :1915-1930.e8.|Cell Rep. 2024 Mar 18;43 (3) :113930.|Chem Eng J. 2024 Sep 15.|Drug Metab Dispos. 2025 Sep 23.|Environ Sci Technol. 2025 Mar 11;59 (9) :4530-4539.|Eur J Med Chem. 2024 Apr 5:269:116344.|Food Science and Human Wellness. 2023 Nov;12 (6) ;2061-2072.|J Hazard Mater. 2025 Mar 29:492:138085.|J Med Chem. 2022 Feb 10;65 (3) :2571-2592.|J Nutr Biochem. 2020 Apr;78:108335.|J Therm Biol. 2024 Jul 2:123:103906.|Methods Mol Biol. 2023:2683:103-111.|Mol Metab. 2024 Oct 29:102053.|Mol Metab. 2025 May:95:102125.|Nat Commun. 2023 Jun 2;14 (1) :3208.|Nat Commun. 2025 Aug 11;16 (1) :7414.|Patent. US20220389379A1.|Phytomedicine. 2025 Oct 11:148:157400.|Redox Biol. 2025 Sep:85:103751.|Sci Rep. 2024 Sep 2;14 (1) :20370.|bioRxiv. 2024 November 15.|BMC Biol. 2025 Apr 24;23 (1) :107.|J Adv Res. 2025 Apr 19:S2090-1232 (25) 00273-5.|J Ethnopharmacol. 2022 Nov 15:298:115622.|JCI Insight. 2021 Jun 22;6 (12) :e142838.|Nat Cell Biol. 2025 Oct 15.|Sci Adv. 2024 Feb 9;10 (6) :eadk3931.

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