Ganoderic acid Mk

• Description :

  Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research[1][2].

• Product Name Alternative :

  GA-Mk

• UNSPSC :

  12352211

• Target :

  Apoptosis; Caspase; MMP; Reactive Oxygen Species (ROS)

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ganoderic-acid-mk.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(/C(C)=C/CC(C(C1CC([C@@]2(C)C3=CCC4[C@](C)(CCC(C4(C)C)OC(C)=O)C3=CC[C@]12C)O)C)OC(C)=O)O

• Molecular Formula :

  C34H50O7

• Molecular Weight :

  570.76

• References & Citations :

  [1]Liu R M, et al. Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells[J]. Latin American Journal of Pharmacy, 2012, 31 (1) :43-50.|[2]Ding N, et al. Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis. J Pharm Biomed Anal. 2010 Dec 15;53 (5) :1224-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 9

• CAS Number :

  [110024-14-1]